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基本説明
Features: Focuses on pathway integration and metablic flux as fundamental determinants of cell physiology; Describes tools for pathway analysis along with the corresponding software code.
Full Description
Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.
Contents
The Essence of Metabolic EngineeringReview of Cellular MetabolismComprehensive Models for Cellular ReactionsMaterial Balances and Data ConsistencyRegulation of Metabolic PathwaysExamples of Pathway Manipulations: Metabolic Engineering in PracticeMetabolic Pathway Synthesis. Metabolic Flux AnalysisMethods for the Experimental Determination of Metabolic Fluxes by Isotope LabelingApplications of Metabolic Flux AnalysisMetabolic Control AnalysisAnalysis of Structure of Metabolic NetworksFlux Analysis of Metabolic NetworksThermodynamics of Cellular Processes
