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Full Description
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.
Contents
Section I. Chemical BiologyChapter 1Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling ProcessesChapter 2Nitric oxide redox biochemistry in lipid environmentsChapter 3Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitrationChapter 4Systems Approaches to Unraveling Nitric Oxide Response Networks in ProkaryotesSection II. Principles of BiologyA. Nitric Oxide SynthasesChapter 5Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversalChapter 6Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid HydroxylasesChapter 7Regulation of the expression of inducible nitric oxide synthaseChapter 8Molecular Regulation of Inducible Nitric Oxide SynthaseB. Guanylate Cyclase and Cyclic GMPChapter 9Soluble Guanylate Cyclase: Allosteric Activation and Redox RegulationC. Nitric Oxide SignalingChapter 10Untargeted Discovery of NO-modified Proteins Chapter 11Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty AcidsChapter 12Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 Chapter 13The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric OxideD. Regulation of Nitric Oxide ProductionChapter 14Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescenceE. Nitric Oxide and RemodelingChapter 15The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational StudiesF. Nitrite and NitrateChapter 16NO formation from inorganic nitrate and nitrite Chapter 17Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potentialChapter 18Nitrite Therapy for Ischemic SyndromesChapter 19Nitrite and heme globins: Reaction mechanisms and physiological targetsSection III. Principles of PathobiologyA. Nitric Oxide and Cardiovascular FunctionChapter 20Nitric Oxide in Vascular Damage and RegenerationChapter 21Free radicals as atherosclerotic risk-The relation of NO-Chapter 22The role of oxidative stress in endothelial dysfunction and vascular inflammationB. Pathophysiological Mechanisms of Nitric OxideChapter 23Nitric oxide, oxidative stress, immune response and critical careChapter 24Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion InjuryChapter 25Nitric oxide in airway inflammationChapter 26Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance